CSD methods, using ERP data, have been successfully applied to several neuropsychiatric conditions, including alcoholism, to elucidate differences in source activations during cognitive processing (Kamarajan et al., 2014, in press). Adult alcoholics manifest low P3-related source activations during the performance of oddball tasks (Cohen et al. 2002; Hada et al. 2000; Rodriguez Holguin et al. 1999a) and showed changes in topographic activation patterns related to response inhibition (Kamarajan et al. 2005a), reward evaluation (Kamarajan et al. 2012), and language processing (Roopesh et al. 2010). Similar lower activations of P3 sources, as well as differences in CSD topographic patterns, have been reported in HR offspring of alcoholic parents (Hada et al. 2001; Ramachandran et al. 1996; Rodriguez Holguin et al. 1999b).
