Chunk #156 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — D. Neuroticism (Sample 19) vs substance dependence (Samples 1, 2) genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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When we compared these clusters to those identified in Samples 1 and 2, only 30 of 10,000 Monte Carlo simulation trials identified chance overlap that was at least as robust as the true datasets (p = 0.003).