Chunk #155 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — D. Neuroticism (Sample 19) vs substance dependence (Samples 1, 2) genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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There was significant convergence between the genes identified by clustered, nominally-positive SNPs for addiction and those identified in generally similar fashion for association with neuroticism (Uhl et al, in preparation, reanalysis of [121]). Of the 31,110 SNPs with nominal p < 0.05 for comparisons of individuals with high vs low neuroticism scores, 4,623 SNPs lie in 903 clusters that each contain ≥ 4 such SNPs.