Chunk #154 — V. “Generalization” of selected genome wide association results between related disorders and phenotypes — C. Bipolar disorder (Samples 7, 8 and 9) vs substance dependence (Samples 1, 2) genes

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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There was remarkable convergence between the genes identified by clustered, nominally- positive SNPs for addiction and those identified in similar fashion for bipolar disorder (Uhl et al, submitted; reanalysis of [1, 2]). Few of 100,000 Monte Carlo simulation trials identified chance overlaps as significant as those noted in actual data for comparisons between the genes identified by clustered positive SNPs for the NIDA substance dependence vs control comparisons and any of the three bipolar disorder vs control comparison groups. Monte Carlo p values were < 0.00001 for the overlaps between data from samples 1 and 2 vs data from samples 7 and 9. Simulation p value was p = 0.00012 for comparison between data from Samples 1 and 2 vs Sample 8.