The minimum P-values for the main analysis were at rs11579964 (chr1: 222 605 563 bp, P = 1.0×10−7) and rs7647854 (chr3:186 359 477 bp, P = 6.5×10−7; Supplementary Tables S16 and S17). Bioinformatic analyses of 201 SNPs with P < 0.0001 and the 1655 SNPs in moderate linkage disequilibrium (LD, r2 > 0.5) showed no overlap with literature findings in the NHGRI GWAS catalog,14 with transcripts differentially expressed in post-mortem brain samples of individuals with MDD,64 or with SNPs that were genome-wide significant or notable in the PGC association analyses of ADHD, BIP, or schizophrenia. We noted that a few of these 201 SNPs were ±20 kb of genes previously studied in MDD (ADCY9 and PDLIM5),65 or notable in prior hypotheses of the etiology of psychiatric disorders (GRM7, HTR7 and RELN).
