We then conducted a combined meta-analysis across the 4 race/ethnicity groups (non-Hispanic Whites, Hispanic/Latinos, East Asians, and African Americans) for the two alcohol consumption phenotypes. We identified two loci that exceeded genome-wide significance (p<5.0×10−8) with drinks/week in the regions of GCKR (rs4665985, beta=0.04, p=2.26×10−8), and KLB (rs7686419, beta=−0.04, p=3.41×10−10) (Table 2). Consistently, GCKR rs4665985 and KLB rs7686419 were also associated with drinker status (p=5.0×10−4 and 4.08×10−5, respectively). Regional Manhattan plots on chromosome 2 and 4 near GCKR and KLB, respectively, are shown in Figure 2. Results for each individual race/ethnicity group are also presented in Table 2, showing no evidence of heterogeneity.
