Finally, we investigated a total of 12 SNPs (6 SNPs for European ancestry subjects, 4 SNPs for East Asian ancestry subjects, and 2 SNPs for African ancestry subjects) associated with alcohol consumption-related traits (e.g. MaxDrinks) at a genome-wide significance level in previous studies (Supplementary Table 1).26–29, 41–43 In non-Hispanic whites, the strongest evidence of association was obtained for GCKR rs780094 and KLB rs11940694 (the same two loci identified in our meta-analysis) with drinks/week (beta=−0.034, Bonferroni-corrected p=2.86 × 10−6 and beta=−0.035, p=1.64 × 10−6, respectively) (Table 3). The same two SNPs were also associated with drinker status in a consistent direction (OR=0.96, Bonferroni-corrected p=0.013 and OR=0.95, p=0.002, respectively). These findings are consistent with the recent report from Schumann et al., who observed genome-wide significant associations for these two SNPs, in their discovery GWAS and in their combined discovery and replication data of European descent, respectively.29 However, when we repeated the analyses, conditioning on our most strongly associated SNPs from our trans-ethnic meta-analysis (rs4665985 at GCKR and rs7686419 at KLB), GCKR rs780094 and KLB rs11940694 did not remain significant (p=0.10 and 0.38,
