of European descent, respectively.29 However, when we repeated the analyses, conditioning on our most strongly associated SNPs from our trans-ethnic meta-analysis (rs4665985 at GCKR and rs7686419 at KLB), GCKR rs780094 and KLB rs11940694 did not remain significant (p=0.10 and 0.38, respectively), suggesting that our top associated SNPs and theirs represent the same signals at those two loci. We also confirmed the association between AUTS2 rs6943555 and drinks/week (beta=0.03, Bonferroni-corrected p=0.005) and a consistent but not significant association with drinker status. This SNP was previously associated with MaxDrinks in a meta-analysis combining 26,316 European-ancestry individuals.27 In non-Hispanic whites, we further detected weak suggestive associations of drinks/week (but not drinker status) with rs1799876 in SERPINC1 and drinker status (but not drinks/week) with rs11128951 at the SGOL1 locus, both of which were previously associated with MaxDrinks.26, 28 In East Asians, we observed genome-wide significant associations with alcohol drinker status for the 4 SNPs tested in the region of 12q24. None of these association signals remained significant, however, after conditioning on rs671 (our most strongly associated SNP), indicating that these SNPs do not contribute independently to variation in alcohol consumption in East Asians (Figure 1. b). In African Americans, the LOC100507053/ADH1B loci with SNPs
