signals remained significant, however, after conditioning on rs671 (our most strongly associated SNP), indicating that these SNPs do not contribute independently to variation in alcohol consumption in East Asians (Figure 1. b). In African Americans, the LOC100507053/ADH1B loci with SNPs rs28864441 and rs2066702 previously associated with MaxDrinks26, showed marginal evidence of association with drinks/week (but not drinker status) in our sample (Table 3). However, we note that the African Americans are the smallest subgroup in our study. Taken together, 3 of the 12 SNPs tested (25.0%) remained significant after Bonferroni correction and conditioning on the most significant SNP in each region. Thus, we confirmed and extended previous findings implicating AUTS2, SGOL1, and SERPINC1 genes in alcohol consumption-related traits in non-Hispanic whites.
