these transcription factors, however, were differentially expressed between HAP and LAP mice. A meta-analysis of whole brain gene expression in three groups of mouse lines selected for high and low ethanol intake (High Short-Term Selection [STS]/Low STS mice which were selected over 3 generations from a C57Bl/6J × DBA/2J reciprocal intercross, and two replicate lines of HAP/LAP mice) and six isogenic mouse strains known to differ markedly in voluntary ethanol consumption (C57Bl/6J, DBA/2J, BALB/cJ, LP/NJ, FVB/NJ and C57Bl/6J × FVB/NJ F1) identified ~3,800 unique genes whose expression levels were correlated with drinking levels [38]. Transcription factor binding sites for Zfp143 were present in the promoter of 64 genes positively correlated with ethanol intake, while consensus sequences for the fork-head box transcription factor Foxa2 were found in the promoter of 146 negatively correlated genes. Importantly, the overrepresented transcription factors had the same pattern of expression as their target genes, i.e. Zfp143 was up-regulated and Foxa2 was down-regulated in mouse models of high ethanol consumption. Although no causal relationship was established, these findings indicate that Zfp143 and Foxa2 could potentially coordinate the expression of genes predisposing to ethanol attraction or rejection. It would be interesting to investigate whether manipulating the expression of
