GO annotation review is an ongoing process with the dual goals of improving annotation consistency and updating annotations to reflect current biological knowledge. While some level of annotation review is continually performed in response to isolated issues, over the past two years, we systematically focused our annotation reviews in two main areas: (i) annotation of gene products involved in transcription, with over 5000 annotations being reviewed, and (ii) use of relations in the annotation extensions (17) that provide context to standard GO annotations, with over 11 000 annotations being reviewed. Several thousand annotations have also been reviewed for smaller scale projects and individual tickets and error reports.
