Bivariate and multivariable GEE analyses of factors associated with MMT discontinuation are presented in Table 2. In bivariable analyses, MMT discontinuation was positively associated with recent homelessness (OR = 2.43, 95% CI: 1.87–3.15), binge alcohol use (OR = 1.48, 95% CI: 1.12–1.96), daily prescription opioid use (OR = 3.02, 95% CI: 1.88–4.84), daily heroin injection (OR = 7.18, 95% CI: 5.62–9.16), daily cocaine injection (OR = 1.85, 95% CI: 1.27–2.69), daily methamphetamine use (OR = 1.75, 95% CI: 1.07–2.85), binge injection drug use (OR = 1.65, 95% CI: 1.25–2.17), recent incarceration (OR = 2.29, 95% CI: 1.64–3.20), and not being on income assistance (OR = 1.98, 95% CI: 1.25–3.14). MMT discontinuation was negatively associated with age (OR = 0.96, 95% CI: 0.95–0.98), having a greater proportion of consecutive follow-ups on MMT (OR = 0.38, 95% CI: 0.29– 0.50), being on methadone dose between 60 and 100 mg per day (vs. ≤60 mg per day) (OR = 0.62, 95% CI: 0.48–0.81) and >100 mg per day (vs. ≤60 mg per day) (OR = 0.28, 95% CI: 0.20–0.39) at the most recent follow-up.
