Chunk #37 — Converging Pathways Implicated in Neurogenesis and AD Pathology — Wnt, reelin and the low-density lipoprotein receptor family in neurogenesis and AD
CA3 regions of the hippocampus (Pesold et al., 1998; Ramos-Moreno et al., 2006). Reelin expression has been shown to mediate the migration of neuroblasts and direct cell fate determination of adult NSC (Heinrich et al., 2006; Won et al., 2006; Zhao et al., 2007; Gong et al., 2007). F-spondin has also been implicated in neuroblast chain formation in the rostral-migratory-stream (Andrade et al., 2007). In summary, increasing evidence points towards a role for numerous LDL receptor ligands and pathways in neurogenesis, most of which are associated with AD, providing further support for a mechanistic link between these processes.
