between major depression and alcohol dependence. However, they also observed negative genetic correlations between major depression and frequency of alcohol consumption. Further, the same trend in attention-deficit/hyperactivity disorder (ADHD) was observed such that problematic drinking was positively genetically correlated with ADHD and alcohol consumption was negatively genetically correlated with ADHD (Sanchez-Roige et al., 2019a). Future work might benefit from additional MR analyses examining the potential causal relations between PTSD and more alcohol phenotypes.
