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Chunk #17 — Results

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Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
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Many genes are linked to NMDAR functions. We selected seventeen genes closely related to NMDAR functions for study: three NMDAR subunit genes (GRIN1, GRIN2A, and GRIN2B), ten genes encoding protein kinases, protein phosphatases and protein palmitoyltransferase, which perform post-translational modifications of NMDAR (FYN, SRC, PRKCG, PTPN5, PPP1CA, PPP1CB, PPP1CC, PPP1R1B, PPP1R9B, and ZDHHC3), and four genes encoding proteins that regulate NMDAR function (DISC1, NRG1, DAOA, and DTNBP1).