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Chunk #50 — SEX DIFFERENCES IN MOLECULAR GENETIC STUDIES — Rare variants and CNVs

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Using the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders.
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result from, or are in the etiologic pathway of neuropsychiatric disorders. 131 Recently, Xia and colleagues 132 investigated the contribution of DNA methylation to sex differences in psychiatric disorders, and reported thousands of sex‐differentially methylated positions (DMPs) and regions (DMRs). Examining sex‐specific methylation and expression may be an important and underexplored avenue of research; the differential response by sex to environmental stress, as indexed by DNA methylation, may inform the differential expression of neuropsychiatric phenotypes by sex.