The GWAS meta-analysis of the UKB and 23andMe samples found 15 independent GWAS signals (Supplementary Table 12) associated with AUDIT total score spanning 10 genomic loci (Table 1). Figure 1 shows the Manhattan and QQ plots of the GWAS meta-analysis of AUDIT total score and Supplementary Figures 5–14 show the regional association plots for the independent signals. The inflation factor of the meta-analysis GWAS was λGC = 1.22 with an LDSC intercept of 1.008 (SE = 0.007), suggesting that the majority of the inflation is due to polygenicity. The 15 independent SNPs show 100% sign concordance for association with AUDIT total score across UKB and 23andMe (Table 1); 11 of these SNPs were nominally associated with AUDIT total score in 23andMe (p ≤ 0.05), and all index SNPs were associated with AUDIT total score in UKB (p < 1.8 × 10−6).
