The top hit for the GWAS meta-analysis of AUDIT total score was a variant (rs11733695) located downstream (879 base pairs) from ADH6 (p = 3.4 × 10−30), which is a member of the alcohol dehydrogenase gene family.rs11733695 is in low LD (r2 = 0.17) with the functional SNP in ADH1B, rs1229984, which is known to alter alcohol metabolism (26). In addition, two other regions in 4q23 were associated with AUDIT total score in the meta-analysis: one of the index SNPs was located in the ADH1C gene; however, conditional analysis of this region in UKB alone suggests that these multiple hits may in fact be tagging the rs1229984 signal. This region has been previously associated with alcohol consumption, AUD, and AUDIT scores (6, 7, 9, 10)
