We also replicated the association between KLB (Supplementary Table 12), on chromosome 4q14, and alcohol consumption (9, 11, 12); the index SNP rs11940694, which is located in the intron of KLB, was associated with AUDIT total score in the present study. Clump based pruning identified rs11940694 and rs4975012 as independent hits in the KLB region. Credible set analysis suggests that rs2046330 is the index SNP in the region represented by rs4975012 (Supplementary Table 13). AUDIT total score was also associated with SNPs that localized to GCKR on chromosome 2p23.3, which has been previously associated with alcohol consumption (9, 11). Five SNPs comprised the credible set at the GCKR locus, which also spans the SNX17 gene, including the missense variant (rs1260326) in GCKR that was identified as the index SNP.
