Over the past 15 years, the National Cancer Institute (NCI) of the National Institutes of Health (NIH) has supported TD teamscience with the goals of catalyzing innovation and accelerating scientific progress. It has funded multiple large initiatives supporting TD research centers addressing major challenges relevant in fighting cancer, including tobacco use, cancer communication, health disparities, and the relationship between obesity and cancer [15- 19]. The NCI has simultaneously supported an internal Science of Team Science (SciTS) team that has conducted improvement-oriented evaluation of these TD center initiatives and generated new knowledge about the processes and impacts of TD team science, as compared to traditional research approaches [2,6,7,20-23].