Lastly, we examined whether the genetic architecture of externalizing converges to similar cell type enrichment across suicide deaths vs deaths from other causes (Figure 4A). Figure 4B demonstrates the cell-type clusters for comparison. We observed significant enrichment within inhibitory neurons, astroglia, and oligodendrocyte progenitor cells (OPCs) in the meta-analyzed results (Figure 4C); however, only the inhibitory neurons were significant in the AFR-like results, a finding that is likely attributable to lower statistical power.
