Cladistic clustering of the 5 most common rhesus haplotypes demonstrated there to be 2 major haplotype clades (Figure 2, cluster 1= H1, H3-H5 and cluster 2= H2). Using data from European (CEU), African (YRI) and Asian (ASN) human populations for comparison, we also generated cladograms for the human CRH locus (Figure 2). The most common haplotypes (rhCRH-H1 in Rhesus macaque and C1 haplotype cluster in human) share most alleles with the ancestral sequence (data not shown). The African population (YRI) shows more haplotype complexity at the CRH locus than does the Caucasian (CEU) population (Figure 2), whereas all Asians were clustered in C1. The cladograms also demonstrate the existence of alternative (yin-yang) haplotpe clades in both species.
