Glucocorticoids are critical to regulation of the CRH system, and among the SNPs that differed between the 2 major haplotype clades was one that was present in a consensus GRE half-site (-2232 C/G, boxed in Figure 1B) 38, 39. Rhesus exhibited only 92% sequence similarity with humans for the 173bp surrounding this site (-2341>-2168), but among all primate species screened, the GRE half-site within this sequence was 100% conserved (data not shown). In silico analysis indicated that -2232C>G would result in complete disruption of this GRE.
