With continued support from the NIMH (and new support from NIDA), the PGC recently initiated a program of research designed to deliver “actionable” findings, genomic results that (a) reveal the fundamental biology, (b) inform clinical practice, and (c) deliver new therapeutic targets. This is the central idea of the PGC: to convert the family history risk factor into biologically, clinically, and therapeutically meaningful insights. This program of research has six aims, three focused on common variation and three on rare variation (Table 1c).
