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Chunk #97 — Results and discussion — Analysis of Akt/mTOR phosphoprotein pathway throughout the brain after chronic alcohol: Decreased expression of multiple mTOR/Akt phosphoproteins in 3xTg-AD alcohol-exposed mice (1-month post alcohol) — Amygdala

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Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
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In the AMY, a history of alcohol drinking was associated with a significant decrease in pERK1/2/MAPT1/2 [t(7) = 1.905, P = 0.049]. No other significant changes were observed; however, trends toward a reduction were observed subregions of the HPC and entorhinal cortex (Table 3).