Chunk #96 — Results and discussion — Analysis of Akt/mTOR phosphoprotein pathway throughout the brain after chronic alcohol: Decreased expression of multiple mTOR/Akt phosphoproteins in 3xTg-AD alcohol-exposed mice (1-month post alcohol) — Entorhinal cortex
= 1.905, P = 0.047], IR [t(8) = 2.211, P = 0.029], and PTEN [t(8) = 1.976, P = 0.042]; while in the MEC, GSK3α [t(7) = 2.590, P = 0.018], IGF1R [t(7) = 2.949, P = 0.011], IRS1 [t(7) = 3.249, P = 0.007], and RPS6 [t(7) = 2.104, P = 0.037] were all significantly reduced when compared to saccharin drinkers.
