Figures 1 shows the Manhattan plot for the association results in the meta-analysis (lambda = 1.004) for the 15,537,641 SNPs (genotyped and imputed) for the EA (lambda = 1.034) and AA GWAS (lambda = 1.026). We identified 3 independent, genome-wide significant (GWS) SNPs in the meta analysis. The top SNP (p = 3.91×10−9) rs2376620, was on chromosome 6 in the CDKN1A (cyclin dependent kinase inhibitor 1A) gene. Inspection of the ancestry-specific results showed this effect was driven primarily by the association in EA families (p = 2.43×10−8, MAF = 0.148). Although this SNP was not significantly associated in the AA families (p = 0.009, MAF = 0.242), the association was in the same direction, which improved evidence of association in the meta-analysis. The next SNP identified in the meta-analysis was rs2433198 (p = 1.78×10−8) in the region GCOM1/MYZAP (GRINL1A complex locus /myocardial zonula adherens protein) on chromosome 15, with support from both the EA families (p = 8.75×10−6, MAF = 0.450) and the AA families (p = 2.86×10−4, MAF = 0.467). The final GWS SNP rs12928255 (p = 1.93×10−8) was
