locus /myocardial zonula adherens protein) on chromosome 15, with support from both the EA families (p = 8.75×10−6, MAF = 0.450) and the AA families (p = 2.86×10−4, MAF = 0.467). The final GWS SNP rs12928255 (p = 1.93×10−8) was in the PKD1L2 (polycystin 1 like 2) gene on chromosome 16, driven by associations in both EA families (p = 1.26×10−7, MAF = 0.381) and AA families (p = 0.024, MAF = 0.218). All independent SNPs with p < 1.0×10−7 from the meta analysis are shown in Table II. Estimates of SNP-based heritability (h2snp) from the summary statistics using LD score regression (Bulik-Sullivan et al., 2015) did not differ significantly from zero in either the EA or AA results.
