Gene-based analyses partially confirmed findings from the GWAS. Figure 2 presents the gene-based Manhattan plot of the meta-analyzed results. Gene-based meta-analysis revealed significant association in the GCOM1/MYZAP region on chromosome 15 (p = 8.09 × 10−7). Additionally, all three genome-wide findings are in genes with chromatin and eQTL interactions with other nearby genes (see supplemental information for detailed plots).
