We present a heuristic model of how to integrate and transform information generated by the vast array of recent neuroscience studies into guided principles toward treatment of OCD patients. Although a neurocircuit-based taxonomy for OCD is still in its nascent stage, knowledge accumulated in the last few decades regarding different neurocognitive functions relevant to OCD and their underlying neural mechanisms can provide insights into possible disease mechanisms and potential novel neurocircuit-based treatment targets. Given that the current diagnostic approach [1–2] of defining mental disorders by groups of symptoms does not demonstrate robust and reliable circuitry abnormalities across individuals diagnosed with the same disorder, treatments targeting specific circuits open the possibility of addressing their underlying symptomatology rather than the disorder as a whole [192]. If specific alterations in circuits governing functions like fear, subjective sensory experiences, habitual behaviors, response inhibition, reward and executive function define particular clinical profiles of OCD, then therapies targeting specific circuits and corresponding clinical profiles could be developed. Since OCD phenotypes involve overlapping circuits, we speculate that successful treatment of OCD will necessitate addressing multiple circuits, according
