Following earlier work indicating theta event-related oscillations (EROs) are associated with the P300 event-related potential (ERP), whose amplitude is negatively associated with FHP,189,190 a Family Based Association Test (FBAT) was carried out on a subset of the COGA sample.191 These authors reported that multiple polymorphisms of the mGlu8 gene are significantly associated with theta EROs and a genetic risk to develop alcoholism.191 A subsequent study by this group confirmed that polymorphisms of the mGlu8 gene are associated with a genetic risk to develop alcohol dependence.192 In another recent study, the mGlu3-rs6465084 polymorphism was found to be significantly associated with alcohol dependence in a male Han Chinese cohort.193
