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Chunk #59 — 4. Discussion — 4.5. Potential Limitations and Suggestions for Future Research

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Random Forest Classification of Alcohol Use Disorder Using EEG Source Functional Connectivity, Neuropsychological Functioning, and Impulsivity Measures.
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Although the current study has yielded interesting findings by identifying important features of EEG source FC, memory performance, and impulsivity in AUD subjects as compared to unaffected controls, we like to acknowledge possible limitations or potential concerns of the current study. First, the sample includes only males, and hence the findings are generalizable only to males with AUD. It would be important for future studies to include both genders, as there are gender differences in brain functional connectivity patterns and prevalence rates of AUD [163,164,165]. Second, although we have confirmed that age per se was not significantly correlated with the significant features discriminating between AUD and control groups, it would be important for future studies to validate our findings using age-matched groups. Third, while family history of AUD has not been analyzed in the current study, it is an important variable to include in the models, and studies are underway in our lab to examine FC measures in high-risk individuals. Fourth, although eLORETA has been reported to have excellent localization accuracy as validated by several multimodal studies, caution needs to