studies have separately shown that AUD was associated with altered rs-fMRI FC [3,161], poor neuropsychological performance [64,150], and heightened impulsivity [65,120], no previous FC studies have examined all three domains together as done in the current study. However, similar to the current study, we also conducted an rs-fMRI FC study, and identified distinct features from all three domains that are involved in the classification of AUD from CTL subjects [54]. Lastly, it may be important to note that previous studies have found associations between eLORETA connectivity and disorder-specific biomarkers such as tau concentrations in Alzheimer’s disease [162] and neurocognitive measures such as MMSE [45], suggesting that EEG source connectivity methods may become a valuable diagnostic tool to detect/predict neuropsychiatric disorders. Therefore, in order to determine potential causal links among features from various domains, future studies may also include comprehensive measures in each domain and implement sophisticated causal pathway analyses, such as multi-level path models.
