ADH1C-rs698 was significantly associated with alcohol disorder phenotypes; the high risk group had a higher prevalence of AD, any AUD, and higher mean values of AD and AUD severity (Table 4). For example, the high risk group had 2.67 times greater odds of AD and 1.47 times higher mean AD severity than the low risk group (Table 4). These results remained significant (p≤0.02) after adjusting for population structure (Table 4) and when controlling for the other SNPs (for rs1229984, p<0.05; for rs1229982, p<0.01; for rs1159918, p<0.003). While risk was elevated for risk drinking (OR=1.5) and maxdrinks (RR=1.2), there was insufficient evidence for significance of these relationships. Furthermore, after controlling for ADH1B-rs1229984, there was no evidence for association of ADH1C-rs698 with consumption phenotypes (risk drinking, OR=1.17, 95% CI=0.60-2.25; maxdrinks, RR=1.03, 95% CI=0.81-1.32).
