Mean values were significantly different from each other for AD, any AUD, and AD and AUD severity, with increased ORs or RRs when comparing diplotype groups (Table 5), suggesting that ADH1B and ADH1C both affect these phenotypes. For example, the intermediate risk group (high risk for ADH1B but not ADH1C) had 2.06 times increased odds of AD compared to the low risk group (low risk for both ADH1B and ADH1C), while the high risk group (high risk for both ADH1B and ADH1C) had 4.31 times increased odds compared to the low risk group and 2.09 times increased odds compared to the intermediate group (Table 5). For risk drinking and maxdrinks, the intermediate-risk and high-risk diplotype groups were not significantly different, suggesting that in this sample, only ADH1B plays a role.
