In this study, we found that variants in two widely studied ADH genes, ADH1B and ADH1C, were associated with multiple alcohol phenotypes in an Israeli household sample, replicating and extending previous studies. Specifically, we found association between ADH1B-rs1229984 and AD, any AUD, risk drinking, AD and AUD severity, and maxdrinks. While we found association between ADH1C-rs698 and AD, AUD, and AD and AUD severity, there was no evidence of association with either risk drinking or maxdrinks. When considered together, joint diplotypes of ADH1B and ADH1C variants were found to influence AD, AUD, and AD and AUD severity.
