Results for associations of ADH1B with AUDs and alcohol consumption are consistent with recent studies of European-ancestry (but not predominantly Jewish) populations (Toth et al., 2011; Bierut et al., 2012) and previous Israeli studies (Neumark et al., 1998; Hasin et al., 2002a; Hasin et al., 2002b; Neumark et al., 2004). We have extended these results by examining binary and count versions of consumption and AD phenotypes, as well as a proxy for the DSM-5 version of AUD that combines AD and AA, in the largest population-based sample of Israeli Jews studied to date. We also tested rs1229982 and rs1159918, functional polymorphisms in the ADH1B promoter region that were previously associated with alcohol-related phenotypes (Pochareddy & Edenberg, 2011) to ensure that rs1229984 associations were not due to correlation with these other SNPs. In this sample, the promoter polymorphisms were either weakly associated with alcohol-related traits (rs1229982) or not associated (rs1159918). The similar allele frequencies observed between the ADH1B SNPs suggests that these results were not merely due to low power. Furthermore, the weak associations with rs1229982 were not significant after controlling
