associated with alcohol-related traits (rs1229982) or not associated (rs1159918). The similar allele frequencies observed between the ADH1B SNPs suggests that these results were not merely due to low power. Furthermore, the weak associations with rs1229982 were not significant after controlling for rs1229984, suggesting that the observed rs1229982 associations were due to correlation between rs1229982 and rs1229984 (r2=0.67). Thus, rs1229984, which has a known functional role in affecting the kinetic properties of the encoded enzyme, is more likely to be the relevant polymorphism.
