As a consequence of the sex-specific genotypic associations, trajectories of phenotypes when effects of sex and genotype are modeled show strong age-specific sex and genotype effects, as illustrated in the plots of the visual Fz phenotype of the four KCNJ6 SNPs studied in this analysis (Figure 6). Among the features, also observable in the previous plots, are opposite genotypic effects in males and females for rs1787422 and age reversal of genotypic effects in males for rs858008. The effect of family type (alcoholic or community family) was not significant using the same statistical methods as used for the genotypic variables, that is, controlling the false discovery rate to be less than 5%. This indicates that family history with regard to alcohol use disorders had little effect upon the phenotypic trajectories presented in the current study.
