paperKB
coga / coga-kb
Help
Sign in

Chunk #61 — 4. Discussion — 4.1. Introduction — 4.1.1. Phenotypic development

Source
Genetic correlates of the development of theta event related oscillations in adolescents and young adults.
Embedded
yes

Text

The features of development found in the previous study (Chorlian et al., 2015), a general decrease in power with age, striking differences in temporal pattern between males and females, and increases in cross-regional and cross-modal phenotypic correlation, are consistent with important features of brain development. The general decrease in power corresponds to the neuronal level decrease in gray matter density and cortical thickness in adolescence, probably reflecting synaptic pruning and myelination, and an increase in white matter (Sowell et al., 2004; Toga et al., 2006). The sex-specific phenotypic divergence corresponds on the structural and functional levels to the considerable sex differences in the trajectories of the development of features of brain anatomy (Lenroot and Giedd, 2010; Lenroot et al., 2007; Peper et al., 2011; Koolschijn and Crone, 2013) and in task-related brain activity (Rubia et al., 2006; Christakou et al., 2009; Rubia et al., 2010; Sumich et al., 2012; Rubia et al., 2013; Rubia, 2013). The increases in cross-regional and cross-modal phenotypic correlation correspond to the development of brain networks from a pattern of local connectivity to more global patterns