We further examined the function of the 47 genes selected by cross-species ranking by using the ToppFun online tool [26]. ToppFun provides enrichment analysis of candidate genes in many biological categories, including GO terms, biological pathways, human and mouse phenotypes, protein domains, and reference search in PubMed. We presented the results of ToppFun as complementary information for WebGestalt analysis and summarized the results of enriched pathways in Table 7 enriched mouse phenotypes in Table 8 and enriched PubMed citations in Table 9. In the pathway analysis, ToppFun uses a comprehensive collection of pathways from major databases such as KEGG, Reactome, and BioCarta [26]. The most enriched pathway is neuroactive ligand-receptor interaction (p = 5.36 × 10-5). Other significant pathways included GPCR ligand binding and G alpha signaling events; here, GPCR denotes G protein-coupled receptor (Table 7). Moreover, mouse phenotype analysis revealed that our selected genes are involved in neuron-related activity (Table 8). Overall, pathway and mouse phenotype enrichment analyses confirmed the results obtained from the GO term enrichment analysis by WebGestalt, and these analyses also revealed highlighted genes related to
