Additional details on the datasets that comprise the PTSD and AD summary statistics (e.g., male/female breakdown, age, trauma type for PTSD) are available in the supplemental material. PTSD summary statistics came from the PGC-PTSD Freeze 2 dataset (PTSD-PGC2; Nievergelt et al., 2019) of GWAS summary statistics from EA participants, N = 174,659 (13.3% PTSD positive cases). Case status reflects primarily lifetime PTSD diagnosis (although it includes current diagnosis when lifetime was not available). PTSD-PGC2 includes subjects from 9 studies already reported in the initial paper (Duncan et al. 2018), 47 new studies (together forming Freeze 1.5) of which 42 were included in the EA summary files, and the large European ancestry UK Biobank study. The UK Biobank cohort is a population-based study and is comprised of few to no subjects who experienced military-related trauma. Conversely, the PGC1.5 cohort is made of a substantial portion of men from military cohorts, while most women in the sample are from civilian studies (Nievergelt et al., 2019).
