AD summary statistics came from the PGC Substance Use Disorders (SUD) workgroup (Walters et al., 2018) EA participants, N = 38,686 (26.4% AD positive cases). Cases were defined as meeting criteria for a DSM-IV (DSM-IIIR for one study) diagnosis of AD and all controls were alcohol exposed. The AD EA sample is comprised of individual genotypic data from 13 case/control studies and 9 family-based studies as well as summary statistics from GWAS of AD from additional cohorts, including both inpatient and outpatient samples and population-based studies. Only one family member was included in the summary statistics from family-based studies; thus, the summary statistics are comprised of only unrelated individuals.
