Chunk #32 — Discussion — Interaction of life events and 5-HTTLPR in the two genders

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Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms.

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Analysing the two genders separately, we found that all significant associations disappeared in women, whereas, in case of men, the interaction effect of the 5-HTTLPR genotype with total life events as well as the interaction effect with financial-related life events was robustly significant in the combined sample and also replicable in the two subsamples.