Chunk #31 — Discussion — Selective effects of recent life events related to financial difficulties in interaction with the 5-HTTLPR genotype in the development of depressive symptoms
not captured in social network- or illness-related life events, which may also account for their closer interaction with 5-HTTLLPR found to be related to threat sensitivity and threat reactivity.27, 28 Further supporting the pervasive impact of severe financial hardships, recently a study reported that childhood poverty was associated with reduced default mode network connectivity in adulthood, which latter was also associated with increased saliva cortisol in anticipation of social stress, indicating a possible neural basis for altered cognitive processing and exaggerated stress sensitivity in adults, which are the key aetiological factors in depression in those suffering from chronic poverty during childhood.60
