Two markers in the HTR1B gene, which encodes a serotonin receptor, had p<10−3. Lee and colleagues (2009) reported that allele frequency at a different marker in this gene, rs130058, differed significantly between individuals categorized as having an anxious/depressed alcoholism subtype versus an antisocial subtype of alcoholism. The SNP was not associated with the alcoholism phenotype per se (in cases versus controls) in that study, although it was in another study (Sun et al., 2002). This marker was not genotyped in the current sample, and the SNPs most proximal to rs130058 are not in high LD with the markers implicated in the current study (r2=0–0.01). LD is also low (r2=0.13) between the markers reported here, suggesting that we are detecting independent signals within HTR1B.
