Analysis of gene expression localization revealed that genes spanning markers with p<10−5 are expressed across many different tissues, and in some cases expression does not appear to be increased in any particular tissue. The same was true of the broader list of genes with p<10−3 (data not shown). We would hypothesize that genes relevant to depressive syndrome and alcohol dependence would be expressed preferentially in the brain or in tissues relevant to the stress response, and indeed that is the case for many, though not all, of these genes.
