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Chunk #12 — Results — Association with SI and ND in the Vand

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Cannabinoid receptor 1 gene association with nicotine dependence.
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Based on the results of single-marker associations that suggest that the signals come largely from markers 5 through 10, we conducted haplotype analyses. In these analyses, marker combination 5-8 showed strong associations with both SI and ND in women; however, the associated haplotypes were different. Table 4 provides a brief summary of the haplotype analyses; complete results are given in eTable 1 (http://www.archgenpsychiatry.com). Other combinations (7-9-10 and 5-7-9-10) showed strong associations with ND but were only marginally associated with SI. As observed in the single-marker associations, these multimarker associations were also sex specific.