To correct for multiple testing, we used the SNPSpD method to estimate the number of equivalent independent tests using the genotype data from this sample. This calculation produced 8 equivalent tests for the 10 SNPs. For both SI and ND, we tested all 10 SNPs for simple χ2 tests and sex-stratified tests in addition to 3 haplotype tests. The total number of tests was 21. Using Bonferroni correction, only rs1049353 survived correction for association with ND; all other single markers failed multiple testing correction. In haplotype testing, although none of the haplotype associations with SI survived correction, all 3 haplotype associations with ND remained significant after the correction.
