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Chunk #14 — Results — Replication of SI and ND in the VAANX Sample

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Cannabinoid receptor 1 gene association with nicotine dependence.
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To verify the findings in the VAND sample, we genotyped the same 10 SNPs in the VAANX sample and conducted sex-stratified analyses directly. For rs2023239, we were able to replicate the female-specific association with SI (main effect P=.01 and sex effect P=.02); rs6928499 showed a trend of association with SI in the same sex (Table 5). For both SNPs, the associated alleles were the same in the 2 samples; rs806368 was nominally significant in the women for the FTND.